Digestion

Probiotics Studied For Clostridioides difficile Infection

Your gut's friendly bacteria act like a packed stadium — every seat is taken, leaving no room for troublemakers to move in. Clostridioides difficile (often called 'C. diff') is an opportunist that waits for those seats to empty, which usually happens after antibiotics clear out large numbers of good bacteria. Once C. diff finds space, it can multiply and cause stubborn, watery diarrhea and significant belly discomfort. It most often strikes people who've recently been on antibiotics or in a hospital setting, and it can be persistent, so it always needs medical attention.

The key to keeping C. diff in check is a full, thriving stadium of beneficial microbes that leaves no open seats. Certain probiotic strains — especially a hardy yeast-based one — have been studied for their role in supporting the gut's natural defenses and helping crowd out unwelcome guests, particularly during and after antibiotic use. Used alongside a doctor's care, they can be a helpful part of rebuilding a resilient gut community and supporting more settled digestion.

Clinical Evidence

Associated Strains

Saccharomyces · CNCM I-745

Saccharomyces boulardii CNCM I-745

This Yeast-Based Probiotic Fights C. diff and Traveler's Diarrhea

Strong

Unlike every other probiotic on this site, Saccharomyces boulardii CNCM I-745 isn't a bacterium at all — it's a beneficial yeast, and that one difference makes it uniquely powerful. Because antibiotics only target bacteria, this probiotic sails right through a course of antibiotics completely unaffected, actively working to protect your gut while the medication does its job. It's one of the most extensively researched probiotics in the world for fighting antibiotic-associated diarrhea, traveler's diarrhea, and the dangerous gut infection caused by C. difficile.

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Medical Disclaimer

The information provided on probioticstrains.com is intended for educational and informational purposes only. It does not constitute medical advice, diagnosis, or treatment. Strain profiles and clinical summaries are compiled from published peer-reviewed literature. While we may evaluate or highlight specific commercial formulations, our insights are always grounded in available scientific evidence. Always consult a qualified healthcare provider before starting, changing, or stopping any supplement or health regimen.